Effects of Aqueous Extract of Moringa oleifera on Phenylhydrazine-induced Liver Toxicity in Wistar Rats

Moringa oleifera has been shown to have a variety of medicinal benefits, including hepatoprotective effects. Phenylhydrazine used cause hepatotoxicity in experimental models. In this study, an aqueous extract was evaluate the ameliorating properties phenylhydrazine-induced liver damage by assessing enzymes and histoarchitecture employing twenty-five (25) mature Wistar rats were divided into five (5) groups. Group A received 1 ml distilled water, B 50 mg/kg phenylhydrazine twice 48 hours, C 500 body weight for four (4) weeks, D hours E forty-eight (48) 70 Silymarin weeks. After administration phenylhydrazine, significant increases (P<0.05) mean concentrations (ALP, AST, ALT) total protein observed, whereas treatment with resulted reversal those parameters values comparable control standard drug - Silymarin. Overall, results showed that had considerable capability against hepatotoxicity.